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, Hong Kong), as well as the avoidance of all people and even food of the "wrong" ethnicity (eg, Chinese)53,54 Similar examples can be cited with regard to cruise ship epidemics hit by the Norwalk-like viruses55 While often treated in the press as a new emerging disease, Norwalk viruses are not a new problem to the cruise industry56 In light of these ndings, it is reasonable to assume that virus-mediated bioterrorism is likely to expand in the future However, in contrast to the complex weapon-grade organisms such as smallpox, today s terrorists are more likely to focus on easily transmitted agents that can be readily propagated in culture or in vivo (eg, martyrdom) Primary among these possibilities will be respiratory viruses that can be ef ciently spread in public locations such as shopping malls, airline ights, and subways.

Fig. 2.4 Logscale diagrams with biscaling. Internet UDP packet data displaying two scaling regimes, examples of biscaling. Left: Delay series. Regime I on the left (small j's) is related to continuous but nondifferentiable sample paths h P 0; 1 and regime II (large j's) to longrange dependence. Right: Loss series (1 for lost packets, else 0). Regime I corresponds to discontinuous sample paths h < 0 . In regime II there is trivial white noise scaling a 0 , indicating stationary SRD behavior.

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One of the best-known examples of a toxic compound being activated in the lung is 4-ipomeanol (Figure 18.4). This naturally occurring furan is produced by the mold Fusarium solani that infects sweet potatoes. Lung edema in cattle is known to be associated with the ingestion of mold-damaged sweet potatoes. A similar pulmonary lesion can be produced in a number of species regardless of the route of administration. Pulmonary injury by 4-ipomeanol is caused, not by the parent compound, but by a highly reactive alkylating metabolite produced in the lung by lung-speci c P450 isozymes. In addition these isozymes are highly concentrated in the Clara cells, which are most affected by 4-ipomeanol toxicity. Although the reactive metabolite has not been identi ed unambiguously, considerable data suggest a reactive epoxide.

the context of delays (left) and losses (right) experienced by consecutive user datagram protocol (UDP) packets sent over the Internet in a regular stream (see Andren et al. [12] for details of such data sets). In both gures the alignment at large scales corresponds to long-range dependence, whereas at small scales it is associated with highly irregular sample paths. Note that when second-order properties are insuf cient to fully describe the scaling nature of the process (an extreme example is afforded by multifractals), then the correct interpretation of each branch of the bisecting will require the examination of logscale diagrams across a range of orders, as discussed in Section 2.3.3. 2.3.2 Estimation Within the Logscale Diagram

Many of these viruses are characterized by a degree of longevity (several hours) within the environment as well as easy transmissibility via hand-to-mouth or inhalational routes Furthermore, many of these viruses can easily be cultured and expanded within the laboratory and, in some cases, enhanced pathogenicity can be selected for via either tissue culture or laboratory animals But perhaps more importantly, for the majority of these agents neither a suitable vaccine nor herd immunity exists due to the rapid mutations noted in respiratory viruses Thus, a broad-spectrum prophylactic antiviral agent would be of signi cant bene t To date, no such agent exists This de cit exists primarily because our current approach to viral prevention is focused primarily on vaccine development and secondly on the treatment of viral diseases once infected.

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In this subsection it is assumed that a scaling range j P j1 ; j2 has been correctly identi ed Sums over j, and regressions, are always taken over this range The estimators to be de ned are semiparametric, as they depend on the range of scales j P j1 ; j2 , where scaling is deemed to be present, and the scaling property P1 valid there, but not on any tightly speci ed parametric model 2321 Estimating the Scaling Exponent a Because of property P1, the measurement of a is reduced to the determination of the slope over the alignment region in the logscale diagram A natural way to achieve this in a statistical estimation context is through linear regression, the de ning hypothesis of which is Eyj a j a, where a is a real constant.

Other toxic lung furans, such as the atmospheric contaminants 2-methylfuran and 3methylfuran, may exert their toxicity through the formation of reactive metabolites, probably reactive aldehydes.

Some pseudoprophylactic agents do exist such as amantadine, which prevents the uncoating of the in uenza A virus, but it is only effective during the very early stages of viral.

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