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as parallel bers, which are oriented along the long axis of the folia and form excitatory synapses with Purkinje cells Each Purkinje cell is in uenced by as many as a million granule cells to produce a single electrical simple spike The predominant afferent input to the cerebellum is via the mossy bers, which are the axons of the spinocerebellar tracts and the projections from pontine, vestibular and reticular nuclei They enter through all three cerebellar peduncles, mainly the middle (pontine input) and inferior (vestibulocerebellar) ones Mossy bers ramify in the granule layer and excite Golgi and granule neurons through special synapses termed cerebellar glomeruli The other main afferent input is via the climbing bers, which originate in the inferior olives and communicate somatosensory, visual, and cerebral cortical signals (Figs 5-4 and 5-5) The climbing bers, so named because of their vine-like con guration around Purkinje cells and their axons, preserve a topographic arrangement from olivary neuronal groups; a similar topographic arrangement is maintained in the Purkinje cell projections The climbing bers have speci c excitatory effects on Purkinje cells that result in prolonged complex spike depolarizations The ring of stellate and basket cells is facilitated by the same parallel bers that excite Purkinje cells, and these smaller cells, in turn, inhibit the Purkinje cells These reciprocal relationships form the feedback loops that permit the exquisitely delicate inhibitory smoothing of limb movements that are lost when the organ is damaged The uniform cortical structure of the cerebellum leads the authors to conjecture that the organ has similar effects on all parts of the cerebrum to which it has projections (cortex, basal ganglia, thalamus, etc) It would follow that the activities of these cerebral structures (motor, cognitive, sensory) would be modulated in a similar way, but this fundamental property of the cerebellum has proved elusive Pharmacologic Considerations A number of pharmacologic and biochemical considerations are of interest Four of the ve cell types of the cerebellar cortex (Purkinje, stellate, basket, Golgi) are inhibitory; the granule cells are an exception and are excitatory Afferent bers to the cerebellum are of three types, two of which have been mentioned above: (1) Mossy bers, which are the main afferent input to the cerebellum, utilize aspartate (2) Climbing bers, which are the axons of cells in the inferior olivary nucleus and project to the Purkinje cells of the opposite cerebellar hemisphere The neurotransmitter of the climbing bers is unknown (3) Aminergic bers, which project through the superior cerebellar peduncle and terminate on the Purkinje and granule cells in all parts of the cerebellar cortex They are of two types: dopaminergic bers, which arise in the ventral mesencephalic tegmentum and project to the interpositus and dentate nuclei and to the granule and Purkinje cells throughout the cortex, and serotonergic neurons, which are located in the raphe nuclei of the brainstem and project diffusely to the granule cell and molecular layer The granule cell axons elaborate the excitatory transmitter glutamate All the inhibitory cerebellar cortical neurons appear to utilize GABA The neurotransmitters of the deep nuclei have not been fully elucidated.

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