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Most of the toxic responses summarized above involve a relatively small number of biochemical events related to oxidative injury, signaling pathways, and genotoxicity. Reactive oxygen species (ROS) such as superoxide anion ( O2 ) and hydroxyl radical ( OH) are balanced by antioxidant enzymes and radical scavengers. Imbalance favoring ROS generation leads to lipid peroxidation, with resultant membrane damage, and DNA damage (genotoxicity). Changes in the concentration of growth factor and/or cytokine signaling molecules may lead to in ammation, proliferative responses, or apoptosis.

Still the Web protocol is responsible for creating some very short interarrival times Once a user starts browsing the Web, he=she usually visits a set of different Web pages This browsing and reading of Web pages generates interarrival times that are of intermediate size Once the browsing session is done a user is likely to take a long break, lets say for lunch, dinner, or even a vacation, thus creating long interarrival times As such, it is no surprise that Web connection interarrival times are heavy tailed We are by no means claiming that the arrival process is a stationary process that can be completely described by an independent identical distribution (iid) arrival process The traces show a substantial dependence on the time of day.

18.4 18.4.1

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existing vaccines However, these agents were dif cult to work with and typically required highly sophisticated research and production facilities as well as complex delivery and decontamination mechanisms Because of these limitations, as well as the traditional governmental powers developing them, viral weapons have not been employed in modern warfare, although it must be mentioned that humankind has historically harnessed nature s own terrors to in ict injury upon one s enemies Historical examples of biowarfare include the trading/donation of blankets from smallpox victims to native North Americans by Lord Jeffrey Amherst and the catapulting of bubonic plague victims over parapet walls50 Modern terrorism is not, however, modern warfare The most successful terrorist actions are often the most simplistic in approach as demonstrated by 9/11 and suicide bombings.

Yet, depending on the application, it might be more important to understand the small time scale behavior than matching a longer time scale behavior To this extent we present evidence that using an iid Weibull model can yield more accurate performance prediction than a nonstationary Poisson process that matches the number of arrivals over time periods as small as minutes Our example application is signaling on a single edge network..

The activation of pulmonary toxicants falls into three main categories or mechanisms, depending either on the site of formation of the activated compound or on the nature of the reactive intermediate. 1. The parent compound may be activated in the liver, with the reactive metabolite then transported by the circulation to the lung. As would be expected, the activated compounds may lead to covalent binding and damage to both liver and lung tissue. 2. A toxicant entering the lung, either from inhaled air or the circulatory system, may be metabolized to the ultimate toxic compound directly within the lung itself. Although the total concentration of P450 is less in the lung than in the liver, the concentration varies considerably in the different cell types, with the highest concentration being found in the nonciliated bronchiolar epithelial (Clara) cells of the terminal bronchioles. Because of this, the Clara cells are often a primary target for the effects of activated chemicals. 3. Another means of metabolic activation is the cyclic reduction/oxidation of the parent compound, resulting in high rates of consumption of NADPH and production of superoxide anion. Either the depletion of NADPH and/or the formation of reactive oxygen radicals could lead to cellular injury. The following three chemicals serve to illustrate these three mechanisms of activation.

The burstiness of connection interarrival times has implications on the design and evaluation of algorithms such as signaling and dynamic routing as well as resource allocation for Web servers. Signaling Signaling consists of two subproblems: connection-admission control and routing. Connection-admission control decides which connections to accept or reject while routing chooses along which (multihop) path through the network to reserve resources. The connection arrival process affects not only the CPU resources necessary to perform the algorithms, but also the network resources required to achieve a desired level of blocking. Depending on a router's CPU resources, it may not be feasible to do an implicit setup for every connection. In this case one has to nd the most bene cial subset and, in addition, a different way of grouping the packets [18]. While different groupings may reduce the burstiness, they do not eliminate it.

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