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graphic appearance of vasospasm, but the clinical manifestations of ischemia depend on additional factors such as collateral blood supply and the cerebral perfusion pressure Hydrocephalus If a large amount of blood ruptures into the ventricular system or oods the basal subarachnoid space, it may nd its way into the ventricles through the foramina of Luschka and Magendie The patient then may become confused or unconscious as a result of acute hydrocephalus The clinical signs are greatly improved by draining the ventricles, either by external ventriculostomy or, in selected cases, by lumbar puncture A subacute hydrocephalus due to blockage of the CSF pathways by blood may appear after 2 to 4 weeks Anatomic-Clinical Correlations of Aneurysms In most patients the neurologic manifestations do not point to the exact site of the aneurysm, but it can often be inferred from the location of the main clot on CT scan A collection of blood in the anterior interhemispheric ssure indicates rupture of an anterior communicating artery aneurysm; in the sylvian ssure, a middle cerebral artery aneurysm; in the anterior perimesencephalic cistern, a posterior communicating or distal basilar artery aneurysm; and so on In some instances clinical signs provide clues to its localization, as follows: (1) third nerve palsy (ptosis, diplopia, dilatation of pupil, and divergent strabismus), as stated above, usually indicates an aneurysm at the junction of the posterior communicating artery and the internal carotid artery the third nerve passes immediately lateral to this point; (2) transient paresis of one or both of the lower limbs at the onset of the hemorrhage suggests an anterior communicating aneurysm that has interfered with the circulation in the anterior cerebral arteries; (3) hemiparesis or aphasia points to an aneurysm at the rst major bifurcation of the middle cerebral artery; (4) unilateral blindness indicates an aneurysm lying anteromedially in the circle of Willis (at the origin of the ophthalmic artery or at the bifurcation of the internal carotid artery); (5) a state of retained consciousness with akinetic mutism or abulia (sometimes associated with paraparesis) favors a location on the anterior communicating artery, with ischemia of or hemorrhage into one or both of the frontal lobes or hypothalamus (with or without acute hydrocephalus); (6) the side on which the aneurysm lies may be indicated by a unilateral preponderance of headache or preretinal hemorrhage, the occurrence of monocular pain, or, rarely, lateralization of an intracranial sound heard at the time of rupture of the aneurysm Sixth nerve palsy, unilateral or bilateral, is usually attributable to raised intracranial pressure and is seldom of localizing value In summary, the clinical sequence of sudden severe headache, vomiting, collapse, relative preservation of consciousness with few or no lateralizing signs, and neck stiffness is diagnostic of subarachnoid hemorrhage due to a ruptured saccular aneurysm Other clinical data may be of assistance in reaching a correct diagnosis Almost all patients are hypertensive for one or several days following the bleed, but preceding hypertension is only slightly more common than in the general population Levels of 200 mmHg systolic are seen occasionally just after rupture, but usually the pressure is elevated only moderately and uctuates with the degree of head pain Spontaneous intracranial bleeding with normal blood pressure should also suggest ruptured aneurysm or arteriovenous malformation and, rarely, hemorrhage into a cerebral tumor Nuchal rigidity is usually present but occasionally absent, and the main complaint of pain may be referable to the interscapular region or even the low back rather than to the head Examination of the fundi frequently reveals smooth-surfaced, sharply.

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outlined collections of blood that cover the retinal vessels the socalled preretinal or subhyaloid hemorrhages; Roth spots are seen occasionally Bilateral Babinski signs are found in the rst few days following rupture if there is hydrocephalus Fever up to 39 C (1022 F) may be seen in the rst week, but most patients are afebrile Rarely, escaping blood enters the subdural space and produces a hematoma, evacuation of which may be lifesaving Laboratory Findings A CT scan will detect blood locally or diffusely in the subarachnoid spaces or within the brain or ventricular system in more than 90 percent of cases and in practically all cases in which the hemorrhage has been severe enough to cause momentary or persistent loss of consciousness (Fig 34-23) This should therefore be the initial investigative procedure The blood may appear as a subtle shadow along the tentorium or in the sylvian or adjacent ssures A large localized collection of subarachnoid blood or a hematoma in brain tissue or within the sylvian ssure indicates the adjacent location of the aneurysm and the likely region of subsequent vasospasm, as already noted When two or more aneurysms are visualized by arteriography, the CT scan may identify the one that had ruptured by the clot that surrounds it Also, coexistent hydrocephalus will be demonstrable If the CT scan documents subarachnoid blood with certainty, a spinal tap is not necessary MRI can also detect blood in the proton density sequence; after a day has passed, this can also be done with the uid attenuated inversion recovery (FLAIR) technique In all other cases, where subarachnoid hemorrhage is suspected but not apparent on imaging studies, a lumbar puncture should be undertaken Usually the CSF becomes grossly bloody within 30 min of the hemorrhage, with RBC counts up to 1 million/

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mm3 or even higher With a relatively mild hemorrhage, there may be only a few thousand cells, but it is unlikely that a severe headache syndrome from subarachnoid hemorrhage would be associated with fewer than a several hundred cells It is also probably not possible for an aneurysm to rupture entirely into brain tissue without some leakage of blood into the subarachnoid uid In other words, the diagnosis of ruptured saccular aneurysm (by lumbar puncture) is essentially excluded if blood is not present in the CSF Xanthochromia is found after centrifugation if several hours or more have elapsed from the moment of the ictus In a patient who reports a headache that is consistent with subarachnoid hemorrhage but the occurrence was several days earlier, the CT scan may be normal and xanthochromia the only diagnostic nding To determine whether xanthochromia is present, fresh CSF must be centrifuged in a tube with a conical bottom and the supernatant compared to clear water in good light It has been our experience that most hospital laboratories cannot be depended on to give accurate results for this test Also helpful after several days is the MRI taken with the FLAIR sequence, which will demonstrate blood (the proton density sequence is more sensitive to blood in the rst day) The problem of a traumatic tap often clouds the early diagnosis and several aids to detecting this misleading laboratory result are discussed in Chap 2 Here it is reiterated that in addition to the absence of xanthochromia, the most important are the clearing of blood as one continues to collect uid and a marked reduction in the number of RBCs in serial tubes of spinal uid A normal opening pressure suggests puncture of a local vessel rather than a ruptured aneurysm The combination of subarachnoid hemorrhage and a traumatic tap generally requires that vascular imaging procedures be performed to resolve the issue The CSF in the rst days.

Figure 34-23 Subarachnoid hemorrhage due to rupture of a basilar artery aneurysm Left: Axial CT scan image at the level of the lateral ventricles showing widespread blood in the subarachnoid spaces and layering within the ventricles with resultant hydrocephalus There is a blood-CSF level in the posterior horns of the lateral ventricles, typical of recent bleeding Right: At the level of the basal cisterns, blood can be seen surrounding the brainstem, in the anterior sylvian ssures and the anterior interhemispheric ssure The temporal horns of the lateral ventricles are again enlarged, re ecting acute hydrocephalus

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